Postdoc NIMR (London) Bioinformatik

Post Doctoral Fellowship at NIMR

Division of Systems Biology
Reference: NIMR09/585

Computational analysis of vertebrate cis-regulatory sequences

We are offering a 3 year Career Development Fellowship (CDF) which is a training and development position for post-doctoral scientists. Applicants will have recently completed their doctoral studies, are moving into a new research discipline, have limited previous experience of key transferable skills, or are clinically qualified with little or no research experience. A CDF will provide opportunities to develop research project skills and collaborative links with colleagues within the Institute and elsewhere.

The post holder will be expected to use computational approaches to identify and characterise patterns and grammar within existing and novel sets of cis-regulatory sequences, and develop generic models that will describe those patterns and allow prediction of function. The post holder will work alongside and collaborate with experimental biologists.

Applicants will possess a PhD or equivalent in bioinformatics or computational biology, with experience in the manipulation and analysis of large sets of DNA sequences. Experience of working with databases and programming (e.g. perl) in a Unix environment is also essential. A good working knowledge of motif analysis in DNA sequences is desirable.

Salary range is from £27,091 – £32,827 per annum inclusive of London Allowance. MRC final salary Pension Scheme is available.

Situated in Mill Hill, North West London, NIMR is the largest MRC institute, supporting some 70 research groups and 500 bench scientists. The Institute provides excellent training for researchers in a multi-disciplinary environment and is equipped with state of the art facilities. http://www.nimr.mrc.ac.uk/employment/

Informal enquiries can be made to: Dr Greg Elgar, email: G.Elgar@qmul.ac.uk and 020 7882 3049.

If you would like to receive this advert in large print, Braille, audio, or electronic format/ hard copy, please contact the Recruitment team at the MRC Shared Service Centre on the telephone number below or recruitment@ssc.mrc.ac.uk

Applications, along with a full CV & Covering letter, should be made online at http://jobs.mrc.ac.uk. If you do not have internet access or you experience technical difficulties please call 01793 301260 quoting reference NIMR09/585.

The closing date is: 8 December 2009
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++++++++++++++++++++++++++++++++++++++++
Greg Elgar PhD
Reader in Functional Genomics
School of Biological and Chemical Sciences
Queen Mary, University of London
Mile End Road, London E1 4NS

http://www.sbcs.qmul.ac.uk/people/greg_elgar.shtml
http://www2.sbcs.qmul.ac.uk/staff/greg_elgar
http://www.biology.qmul.ac.uk/research/staff/elgar/index.htm
http://fugu.biology.qmul.ac.uk
http://condor.fugu.biology.qmul.ac.uk/

Doktorarbeit mRNA-protein interaction modeling in Basel

PhD position: modeling RNA-protein interactions and inferring post-transcriptional regulatory codes

In the recent years it became apparent that normal development
involves regulatory interactions of proteins and non-coding RNAs with
target mRNAs, whose lifetime and protein output is thereby
modulated. Over-expression of specific RNA-binding proteins as well as
of regulatory RNAs such as miRNAs have been associated with various
diseases, in particular with cancers. Developments in sequencing
technologies coupled with novel experimental protocols yield large
numbers of binding sites for various regulators. Analyses of such
binding sites, together with various types of physical measurements
(affinities of interactions, structure of regulator-target complexes,
etc.) should enable us to understand and subsequently predict with
high accuracy binding sites genome-wide and to study the extent and
structure of these regulatory networks.

The group of Mihaela Zavolan (Biozentrum Basel and Swiss Institute of
Bioinformatics) aims to understand the logic and function of
post-transcriptional regulation of gene expression during basic cell
function, development and cancer. For this purpose we generate,
analyze and computationally model large high-throughput biological
data sets. We currently seek a highly motivated PhD student with a
very strong quantitative background, interested to join our highly
dynamic research group in order to investigate the logic of RNA
binding protein – target interactions and the function of these
interactions in normal and pathological conditions.

Relevant references

Relative contribution of sequence and structure features to the mRNA
binding of Argonaute/EIF2C-miRNA complexes and the degradation of
miRNA targets. Hausser J, Landthaler M, Jaskiewicz L, Gaidatzis D,
Zavolan M. Genome Res. 2009 Sep 18. [Epub ahead of print]

Inference of miRNA targets using evolutionary conservation and pathway
analysis. Gaidatzis D, van Nimwegen E, Hausser J, Zavolan M. BMC
Bioinformatics. 2007 Mar 1;8:69.

Requirements

We are looking for candidates with a background computer science,
physics/biophysics, applied mathematics, computational biology or
bioinformatics, and a demonstrated ability to perform
research. Candidates should have experience in programming, preferably
in C/C++ and a scripting language like Perl or Python. Although a
formal training in molecular biology is not required the succesful
candidates will be expected to collaborate closely with experimental
colleagues and good communication skills are highly desirable.

Please submit your application letter, CV and the contact information
of two references before December 15, 2009 to:

Prof. Mihaela Zavolan
Biozentrum Universität Basel
SIB – Swiss Institute of Bioinformatics
Klingelbergstrasse 50-70
4056 Basel Switzerland
email: mihaela.zavolan[at]unibas.ch

Postdoc am MIT Computational Biology

Subject: Postdoctoral positions available in MIT Computational Biology group

The MIT Computational Biology group (compbio.mit.edu) is seeking highly motivated postdocs to undertake exciting new projects in computational and regulatory genomics. We seek applicants with a strong background in machine learning, algorithm development, statistical methods, and their applications to computational biology, gene regulation, epigenomics, and integration of large-scale biological datasets.

Our group is part of the MIT Computer Science and Artificial Intelligence Lab, and of the Broad Institute of MIT and Harvard, leading to a truly interdisciplinary environment. We have numerous ongoing collaborations with experimental and biological groups, and are part of the NIH ENCODE, modENCODE, and Epigenome Roadmap collaborative projects where our group plays a leadership role in data analysis and integration.

For more information about the group, please visit: http://compbio.mit.edu/

Applicants are sought for the following ongoing projects:
(1) Integrative analysis of genomic and epigenomic datasets in the human genome, in the context of the NIH Epigenome Roadmap and ENCODE projects. Goal is to use many chromatin marks in multiple cell types in order to discover and interpret chromatin states, understand their biological roles, and their dynamics in differentiation and disease (NIH RC1-HG005334, NIH U54-HG004570).

(2) Integrative analysis of the Drosophila modENCODE project. Goal is to systematically understand the functional elements encoded in the fly genome, and the regulatory logic defining transcription factor binding and chromatin domains, and guiding developmental programs (NIH RC2-HG005639, NIH U54-HG004555).

(3) Regulatory genomics in human and fly genomes. Goal is to discover regulatory motifs, enhancers, and cis-regulatory modules in the human and fly genomes, and develop predictive models of gene regulation using comparative genomics and large-scale experimental datasets (NIH R01-HG004037).

(4) Role of non-coding RNAs in chromatin. Goal is to understand the role of small and large non-coding RNAs in directing, establishing, and maintaining chromatin modifications in human embryonic stem cells and during differentiation and cancer (Collaborative work with Ron Hart at Rutgers and John Rinn at HMS).

(5) Additional projects are available in comparative genomics, genome interpretation, microRNA regulation, phylogenomics, image analysis, RNA structure, and applicants are welcome to define their own projects within the context of ongoing activities in the group (NSF 0644282, NIH U01-HG004264, NSF 0936234).

For more information about open positions, please visit: http://compbio.mit.edu/positions.html
or contact Prof. Manolis Kellis directly at .

Gruppenleiter in Sydney

We have faculty position(s) vacant at the Victor Chang Cardiac Research Institute (VCCRI) in Sydney, which have been advertised in Science and online (see advertisement text copied below).

Perhaps you are thinking of moving to a new post. Or you know of someone who might be interested and a suitable candidate, in this case please let them know.

I’d be happy to serve as an initial point of contact for anyone wishing to find out more.

With many thanks,

Thomas.

Advertisement text:

The Victor Chang Cardiac Research Institute (VCCRI) is seeking faculty members at the Senior Lecturer, Associate Professor or Professor levels. Applicants will be expected to hold a PhD or MD with relevant postdoctoral training, and will have a track record of outstanding research achievements at an international level that has attracted highly competitive peer-reviewed funding. Particularly encouraged to apply are those that address gene regulation at the
transcriptional or post-transcriptional levels; vascular biology, particularly in terms of neoangiogenesis or vasoregulatory mechanisms; stem cell biology and therapeutic approaches; structural biology; genomics; bioinformatics with specific skills in genome profiling, microarray analysis ie systems biology, or tissue bioengineering. Preference will be given to applicants performing ‘cutting-edge’ research in areas of cardiovascular science or in disciplines that are
relevant to understanding cardiovascular biology or disease pathogenesis at the physiological, molecular, cellular and structural levels.

The VCCRI provides an outstanding scientific environment with established strength in developmental biology, gene regulation and epigenetics, molecular cardiology and biophysics, structural and computational biology, and cardiac mechanics and transplantation biology.

The successful candidate will be provided with laboratory space and significant financial support to rapidly establish their program, and will be eligible for an academic appointment at the University of New South Wales. Details of the Institute, its programs and faculty are available at: http://www.victorchang.edu.au

To apply, submit a CV, the names/contact information of three referees, and a statement of past research achievements and anticipated research directions by 1 December 2009 to the Human Resources Manager, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW, 2010, Australia, or email: c.northam@victorchang.edu.au

For further information about the Institute visit http://www.victorchang.com.au

This job description also appeared online:
http://scjobs.sciencemag.org/JobSeekerX/ViewJob.asp?cjid=35352&accountno=103&keywords=victor+AND+chang
http://www.nature.com/naturejobs/science/jobs/115279-Faculty-Positions
http://www.victorchang.edu.au/public/ResearchEmploymentOpportunities.cfm?cid=28

Postdoc in Oslo

Position as POSTDOCTORAL RESEARCH FELLOW available at
Centre for Immune Regulation, DEPARTMENT OF MOLECULAR BIOSCIENCES,
Faculty of Mathematics and Natural Sciences, University of Oslo

The position is available for a period of two years (possible prolongation)
Project start date: January 1st , 2010 (or as soon as possible)
POSTDOC Immunology_Imaging Oslo

SFI complex systems summer school

PLEASE CIRCULATE:
The Santa Fe Institute announces its 22nd annual Complex Systems
Summer School, June 6-26, 2010, in Santa Fe, New Mexico. Applications
will be accepted November 1, 2009 through January 10, 2010.
The program offers an intensive three-week introduction to complex
behavior in mathematical, physical, living, and social systems for
graduate students and postdoctoral fellows in the sciences and social
sciences. The school is for participants who want background and
hands-on experience to help prepare them to do interdisciplinary
research in areas related to complex systems.
The program consists of lectures, laboratories, and discussion
sessions focusing on foundational ideas, tools, and current topics in
complex systems research. These include nonlinear dynamics and pattern
formation, scaling theory, information theory and computation theory,
adaptation and evolution, network structure and dynamics, adaptive
computation techniques, computer modeling tools, and specific
applications of these core topics to various disciplines. In addition,
participants will formulate and carry out team projects related to
topics covered in the school.
Applications are solicited from graduate students and postdoctoral
fellows in any discipline. Some background in science and mathematics
(including multi-variate calculus and linear algebra) is required.
Proficiency in English is also required. Women, minorities, and
students from developing countries are especially encouraged to apply.
Application Requirements
1. Current resume or CV. Include a clear description of your
current educational or professional status, and a list of
publications, if any.
2. A 1-2 page statement of your current research interests and
comments about why you want to attend the school.
3. Two letters of recommendation from scholars who know your work.
For further information and to apply, please see our web site at:
http://www.santafe.edu/csss

Gruppenleiterstellen/ Senior Postdoc in Istanbul

the Department of Molecular Biology and Genetics at Bogazici University will have four (4) independent research positions available, starting in July 2010.
The positions will be available for an initial 2.5 years but we will see that continuation will be secured after 2013. As you can see from the attached links to Naturejobs and the PDF, we are looking for people with at least 2 years of postdctoral experience and a certain technological background. We can be quite flexible with the actual Job description and candidates can enter either as „postdocs“ or „junior research group leaders“. Salaries will be very competitive for a state school and exceed Asst. Prof. salaries. The add will also be published in print in todays issue of Nature.
BU_Nature_2009

Doktorandenstellen und Postdocstellen am CNIO in Madrid

I would like to draw your attention to the 2010 calls for the International Ph.D. and Postdoctoral Programmes at the Spanish National Cancer Research Centre (CNIO). We would greatly appreciate if you could forward the information about these exciting programmes to potential candidates.

The CNIO offers excellent training and research opportunities in cutting edge basic and applied cancer research. The programmes are open to outstanding young graduates from all over the world who want to pursue ambitious research projects.

The CNIO International Postdoctoral Programme offers up to 6 very competitively funded two-year postdoc positions to outstanding junior scientists. Applications are considered at regular intervals, this call closes on December 31st, 2009.

The CNIO International Ph.D. Programme each year supports 10 candidates for a 4-year Ph.D. We have one selection per year. The deadline for applications is March 15th, 2010.

Our webpage provides further information on both programmes and the application procedure:

- Postdoc Programme: http://www.cnio.es/postdoc

- Ph.D. Programme: http://www.cnio.es/phd

How to choose a good scientific problem

Hervoragender Essay in Molecular Cell von Uri Alon: How to choose a good scientific problem. Für Doktoranden, Postdocs, Gruppenleiter und Profs geeignet.
how to choose a scientific problem

Doktorandenstelle an der Uni Heidelberg

Ribosomal RNA processing
RNA Helikasen, Post-translationale Modifikationen, mathematical modelling
http://www.bzh.uni-heidelberg.de
PhD_BZH